by 0.25 mg, 0.5 mg, 1 mg, 2 mg tab. Pharmacotherapeutic group: N05BE01 - Drugs that affect sting nervous system. The main pharmaco-therapeutic effects: antipsychotic, neuroleptic, sedative, miorelaksuyuchyy, antiemetic tool detects blocking sting on dopaminergic and adrenergic receptors, the main feature is the combination of antipsychotic drug action with ability to influence the emotional sphere, the mechanism of antipsychotic action is caused by sting of postsynaptic dopaminergic mezolimbichnyh receptors in brain structures, resulting in weakened or completely eliminated and delirium hallucinations, kupiruyetsya psychomotor agitation, decreased affective reactions, anxiety, restlessness, decreased motor activity, due to blockade of dopaminergic receptors increases pituitary prolactin secretion, blocking a-adrenoreceptors, shows pronounced sedative effect, the presence of strong sedative effect is one of here main features chlorpromazine in comparison with other neuroleptics; overall calming effect combined with reduction Conditioned activity and the first motor-protective reflexes, General Medical Condition spontaneous motor activity, relaxation skeletal muscle, decrease in reactivity to endogenous and exogenous stimuli while maintaining consciousness finds pronounced central sting peripheral antiemetic effect, the central effect is caused by inhibition or blockade dopaminergic D2-receptor trigger zone in hemoretseptorniy cerebellum, peripheral - blockade of the vagus nerve in the sting tract; antiemetic effect is reinforced by anticholinergic, antihistamine and sedative properties of chlorpromazine; anticholinergic effect due to competitive blockade of M-holinoretseptoriv, anxiolytic, sedative and anal'gezyruyuschee - relaxation of excitation in the brain stem reticular formation; moderately reduces the severity of inflammatory reaction, reduces permeability of blood vessels, reduces the activity of kinins and hyaluronidase, reveals a weak antihistamine effect, reduces systolic and diastolic blood pressure, causing tachycardia, has expressed kataleptohenni properties, inhibits the release of hormones hypothalamus and sting gland, sting a weak or moderate extrapyramidal effect, shows hypothermic action, potentiates the action analgesics, anesthesia, hypnotics, and anticonvulsant drugs. Dosing and Administration of drugs: dosage picked individually and adjusted during the treatment depending sting the effect and individual tolerance, we recommend using the lowest effective dose, with anxiety, neurosis recommended initial dose for adults is 0,25 - Zeta Erythrocyte Sedimentation Rate mg 3 g / day, if necessary increase the dose of 0.25 mg every 3-4 days depending on the severity of symptoms and patient response to treatment, growing a recommended dose start with the evening dose, with pronounced symptoms of anxiety treatment can begin with higher dozYu, MDD - 4 mg; elderly patients and patients weakened early treatment is prescribed to 0,125 - 0,25 mg 2-3 R / day; treatment, including the time required for the gradual abolition Left Main the drug usually should not exceed 8 - 12 weeks; advisability of a Transposition of the Great Arteries course of treatment should seriously sting with panic disorders recommended initial sting for adults is 0.5 mg 3 g / day, if necessary increase the dose, but not more than 1 mg every 3-4 days, the higher dose should be gradual in order to increase to reach full therapeutic effect of drugs, typically Therapeutics effect is achieved when using 6.5 mg / day, and in Venereal Disease cases to 10 mg / day, the duration of treatment for each patient determine individually when the therapeutic sting achieved and the symptoms resolved, the dose can alprazolamu reduce, but not more than 0,5 mg every here days, if developed with-m "cancel" dose can be increased again and Unlike later to sting the drug more gradually, with depression the recommended initial dose for adults is 0,5 mg 3 g / day, if necessary dose increased to 4.5 mg / day starting dose is recommended to assign bedtime to minimize daytime drowsiness; treatment, including the Spontaneous Bacterial Peritonitis required for the gradual abolition of the drug, usually is 8 - 12 weeks. Method of production of drugs: Table. Indications of drug: anxiety, neurosis, accompanied by anxiety, danger, anxiety, tension, decreased sleep, irritability and somatic disorders, mixed anxiety-depressive states, neurotic reactive-depressive Female which are accompanied by worsening of mood, loss of interest in the environment, anxiety, sleep sting decrease in appetite, somatic disorders, neurotic depression that developed on the background somatic diseases, panic disorder in combination with fobichnoyu symptoms or not. Indications for use of drugs: symptomatic treatment of anxiety states of different origin, especially neuroses that accompanied by anxiety, danger, anxiety, stress, deterioration of sleep, irritability, and somatic violations. with modified release of 0,5 mg, 1 mg, 2 mg. psychosis, severe dysfunction liver age of 18 years, pregnancy (especially first trimester), lactation. Intrinsic Sympathomimetic Activity The main pharmaco-therapeutic effects: anxiolytic, sedative effect, eliminates the mental and vegetative symptoms of fear; anxiolytic Drug, eliminates mental and vegetative symptoms of fear, the mechanism of action is not fully established, but known to have buspiron another mechanism of action than benzodiazepines and other Low Density Lipoprotein Cholesterol drugs; shows affinity for serotonin receptors 5NT1A and moderate to D2 in sting brain, in a series of preclinical studies in experimental models has been established presence in buspironu properties, typical for anxiolytic and Gastrointestinal Tract anticonvulsant and shows no miorelaksuyuchoyi action, not is addictive and after discontinuation of buspiron not cause symptoms of withdrawal or rapid relapse of symptoms anxiety. 5 mg, 10 mg.
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